Organically bound and tissue free tritium in rice plant grown around Tarapur Atomic Power Station,west coast of India

Journal of Radioanalytical and Nuclear Chemistry - Tritium concentration in different parts of the rice plants, grown in villages around Tarapur Atomic Power Station, west coast of India, exposed...     

Synthesis of Ferrocene-based Esters as Burning Rate Catalysts and their Anti-migration Study

Ferrocene-based (Fc-based) burning rate catalysts (BRCs) play an essential role in the solid rocket propellants. However, the migration problem during curing and storage limits their applications. To retard the migration problems of Fc-based BRCs and to increase the burning rate (BR) of AP-based propellants, Fc-based esters compounds (Es-Fcs) were synthesized. The synthesized Es-Fcs were characterized by X-ray diffraction, proton nuclear magnetic resonance (¹H NMR),¹³C NMR and Fourier transform infrared (FT-IR) spectroscopy. The electrochemical behaviors of Es-Fcs were investigated by cyclic voltammetry (CV). The BR catalytic activity of Es-Fcs on thermal decomposition of AP were examined by thermogravimetry (TG). Thermal analysis results showed that these Es-Fcs had good BR catalytic effects on thermal decomposition of AP. It was found that the anti-migration performance of Es-Fcs were better than catocene and Fc.     

Application of a UPLC‐MS/MS method for the analysis of alosetron in human plasma to support a bioequivalence study in healthy males and females

A simple, rapid and sensitive ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method has been developed and validated for the determination of alosetron (ALO) in human plasma. The assay method involved solid‐phase extraction of ALO and ALO 13C‐d3 as internal standard (IS) on a LichroSep DVB‐HL (30 mg, 1 cm³) cartridge. The chromatography was performed on an Acquity UPLC BEH C₁₈ (50 × 2.1 mm, 1.7 µm) column using acetonitrile and 2.0 mm ammonium formate, pH 3.0 adjusted with 0.1% formic acid (80:20, v/v) as the mobile phase in an isocratic mode. For quantitative analysis, the multiple reaction monitoring transitions studied were m/z 295.1/201.0 for ALO and m/z 299.1/205.1 for IS in the positive ionization mode. The method was validated over a concentration range of 0.01–10.0 ng/mL for ALO. Post‐column infusion experiment showed no positive or negative peaks in the elution range of the analyte and IS after injection of extracted blank plasma. The extent of ion‐suppression/enhancement, expressed as IS‐normalized matrix factor, varied from 0.96 to 1.04. The assay recovery was within 97–103% for ALO and IS. The method was successfully applied to support a bioequivalence study of 1.0 mg alosetron tablets in 28 healthy Indian male and female subjects. Copyright © 2015 John Wiley & Sons, Ltd.     

Oscillator strength measurements of the 4s5s 3S1 → 4snp 3Po2 Rydberg transitions of zinc

In the present experimental work, oscillator strengths of the 4s5s ³S₁ → 4snp ³P^o₂ (18?≤?n?≤?53) Rydberg transitions of zinc are reported. The stepwise laser excitation from the ground state 4s^{2 1}S₀ was achieved using three dye laser beams simultaneously pumped by the second (532?nm) and third (355?nm) harmonics of a Q-switched Nd: YAG (Neodymium-doped yttrium aluminum garnet) laser. The vapor containment and detection system was a single wire thermionic diode ion detector operating in space charge limited mode. A trend of the above-mentioned f-values from n?=?18 to 53 versus the principle quantum number n has been presented. Furthermore, continuity has been verified between the discrete f-values and the oscillator strength density at the threshold.     

Characterization of new Co(II) complexes and photographic monitoring for their toxic impact on breast cancer cells according to simulation study

Five new nitrogen-rich ligands (thioanhydrides) were synthesized and fully characterized. Then, their corresponding Co(II) complexes were prepared and also elucidated by analytical and spectral conformational techniques. First of all, the mono-negative tri-dentate mode was proposed with all derivatives towards mono-nuclear central atom. According to ligand field transitions and magnetic susceptibility values, the square-planar as well as octahedral geometries were the forms suggested. The presence of water molecules was investigated thermally. For conformational implementation under optimal conditions, energy minimization was carried out and fundamental data were obtained and studied. In silico investigation was carried out using the MOE docking approach to predict the inhibition activity for the new compounds. The Co(II)– 3e complex played an excellent inhibitory role. After that and based on preliminary results, in vitro antitumor screening against MCF-7 cell line was conducted for all Co(II) complexes. The results were consistent with that for standard drug (doxorubicin), and the inhibition feature for the complexes was ranked. Through photographic monitoring, outstanding inhibition activity towards breast cancer spreading was recorded for the Co(II)– 3e complex, which coincides well with MOE docking data.     

Cellulose acetate composite films fabricated with zero-valent iron nanoparticles and its use in the degradation of persistent organic pollutants

Cellulose acetate (CA), and CA blended with Nicotiana tabacum ash (ACA) membranes have synthesized and fabricated with zero-valent Fe NPs (ZVI) and named as CA@Fe⁰ and ACA@Fe⁰. The as-synthesized membranes were inspected for the removal and detoxification of toxic organic pollutants. Comparative studies of CA@Fe⁰ and ACA@Fe⁰ NPs were investigated for five model pollutants, such as 4-nitrophenol (4NP), methyl orange (MO), Congo red (CR), methylene blue (MB), and bromocresol green (BCG). The kinetic model indicated that the apparent rate constant K_app value of ACA@Fe⁰ was highest for all model pollutants compared to CA@Fe⁰ NPs. The K_app value is derived from pseudo-first-order kinetics. The K_app value of MO discoloration was 8.17 × 10⁻¹ min⁻¹ with ACA@Fe⁰ which is highest than CA@Fe⁰ (3.08 × 10⁻¹ min⁻¹). The turnover frequency (TOF) was highest for ACA@Fe⁰ for all the pollutants compared to CA@Fe⁰ and the highest TOF value was found for CR dye with ACA@Fe⁰ which is 0.523 h⁻¹. Both the membranes also showed promising antibacterial activity against Salmonella typhi. Furthermore, CA, ACA membrane and CA@Fe⁰ and ACA@Fe⁰ NPs were characterized through FESEM, EDS, XRD, FTIR and TGA analysis.     

Thermodynamic and Spectroscopic Studies of Pentoxifylline in Aqueous Glucose/Lactose Solutions

Journal of Solution Chemistry - The density, speed of sound and viscosity data of drug pentoxifylline in aqueous solutions of glucose (monosaccharide) and lactose (disaccharide) were determined....     

Study on the performance assessment of a novel hybrid heat pump system modified with dedicated mechanical sub-cooler for domestic heating applications

Journal of Thermal Analysis and Calorimetry - This article investigates the performance of a novel hybrid heat pump system, which is developed to recover the waste heat from the flue gas of...